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Lichen Sclerosus & Crohn's


Fri, February 28, 2025 10:39 PM


Looking to see if anyone else is dealing with lichen sclerosus and Crohn's.  Lichen sclerosus (LS) diagnosed by biopsy.  Topical steroids (Clobetasol, Fluorocinonide) are really not working.  I have now developed pustular psoriasis and plaque psoriasis as well. (Also have Sjogren's, Hashimoto's and Raynaud's, but not as bothersome).  
 Have been on Humira (or biosimilar) for 7 years. Treatment proposed for psoriasis is Wynzora (anhydrous calcipotriene and betamethasone dipropionate).  Yet another horrendously expensive drug.  The most bothersome of all these diseases is the LS.
I go to a gastroenterologist, dermatologist, gynocologist ,opthamologist and primary care (internal medecine) each of whom has prescribed a drug for their specialty area disease.
Any thoughts on LS in the universe of Crohn's? Despite the above, I am doing well, just really itchy.

FPO monarch14
Joined Sep 15, 2014

Sun, May 04, 2025 11:38 PM

Reply posted for monarch14.

There is an increasingly recognized link between diseases like Crohn’s, LS, and other autoimmune diseases like Hashimoto’s or Sjogren’s. They don’t necessarily cause each other, but they stem from the same underlying immune disorder. In this case, considering another biologic regimen like Stelara or Dupixent may be worth considering – especially if there is a severe form of psoriasis.
Among Us

FPO amoralyly
Joined May 4, 2025

Sun, May 04, 2025 11:19 PM

Reply posted for monarch14.

There’s no definitive established link in the literature between LS and Crohn’s, but both are considered immune-mediated conditions. It’s not uncommon for patients with Crohn’s to develop other autoimmune or inflammatory skin conditions. A single biologic that can target both Crohn’s and autoimmune skin issues might help simplify your treatment landscape and reduce flare-ups. 

It might be time to bring your specialists together, at least through shared records or via your primary care physician, to coordinate and potentially optimize your systemic treatment plan — especially since many of your symptoms (Crohn’s, LS, Geometry Dash Lite) might respond to a newer-generation targeted biologic. 

FPO washsparse
Joined May 21, 2024

Mon, April 28, 2025 9:12 PM

Reply posted for monarch14.

The emphasis is on mobility Crazy Cattle 3D and location rather than conventional weaponry in this game.

FPO newcapon
Joined Apr 28, 2025

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