Community Forum

My 18 y/o with Crohns is currently on Imuran (for 8mo. now), though at a level not quite high enough.  He's been on it since Dec, and has been having symptoms/inflamation showing on MRI and in blwk.  Dr. leaning toward biologic, but unsure if we should give Imuran a bit more time at an increased dose 1st?  I am worried to allow inflamation to continue, potentially causing damage, but unsure ready to jump to biologic.  Anyone have success with Imuran?  Or have opinion on this?  He was dx at age 10, and was steady for many years previous to Dec last year.

Reply posted for jrichins.

An editor plays a crucial role in the world of publishing, ensuring that written content is polished and engaging. An Editor carefully reviews manuscripts, articles, and other materials, correcting grammar, punctuation, and style errors while also enhancing clarity and coherence. Beyond just proofreading, an editor often provides valuable feedback on structure and content, guiding authors to strengthen their narratives. In the digital age, the role of an editor has expanded to include overseeing online content, optimizing it for search engines, and ensuring it meets audience expectations. Ultimately, the editor acts as a bridge between the writer’s vision and the reader’s experience.

Reply posted for jrichins.

Bandle Unlimited is not just a fun and engaging game; it also offers cognitive benefits. Playing word games like Bandle can enhance vocabulary, improve spelling, and sharpen strategic thinking skills. 

Reply posted for beccaaa239.

Hi I was taking Humira for around 4 months and have stopped now as am having a very bad skin reaction to it.. anyone else experience this. I have raised red spots and raised hive looking rash on my face and body.. So Itchy and sore its doing my head in and have sore in my scalp which where weeping. Can anyone help with any advice on what they have done for traetment and how long this lasted??

Reply posted for jrichins.

I’ve been on both immuran and methotrexate coupled with Humira for 5 years, then Remicade after developing the antibodies for Humira. The studies show much more effectiveness of a biologic coupled with an immune suppressant. After a year or two on each, however, my body reacted with skin cancers so I had to stop both. I remain on Remicade.  In my early days of crohn’s there were no biologics. Now that they are out there with several options, I am a big believer in them. 

Reply posted for jrichins.

I’ve been on both immuran and methotrexate coupled with Humira for 5 years, then Remicade after developing the antibodies for Humira. The studies show much more effectiveness of a biologic coupled with an immune suppressant. After a year or two on each, however, my body reacted with skin cancers so I had to stop both. I remain on Remicade.  In my early days of crohn’s there were no biologics. Now that they are out there with several options, I am a big believer in them. 

Reply posted for jrichins.

I've had cohns for at least 55 yrs and have been on Imuran total daily dose250 mg, for at least 20-25 yrs. Despite the warnigs, not only has my crohns improved but my environmental allergy symptoms have subsided. I rarely get colds, if ever. This can be attributed to the fact that my hyperactive imune system which contributed to these conditions, including crohns, was brought to "nomal."  I am now 70 and lead an active life with some sometime embarrasing but manageabe flare ups.

Reply posted for acharyamdclint.

Hi! I’m a 19 year old with Crohn’s and I was diagnosed at 12. I have been imuran for about 3 years now. I was previously on Humira and it had bad effects for me. The Imuran seems to work during remission but during a flare it is not the most helpful.

Reply posted for jrichins.

I came to know that the medicines used for Crohn's diesase have side-effects like getting infections (including TB) and cancer, if taken for long time.

Therefore I want to know whether there is any safe treatment for Crohn's disease?

Is your child having crohn's disease of the small instestines or the colon?

Please share your problems to my email: acharyamdcl.int@gmail.com

Reply posted for marck.

For Crohns, I have taken Imuran, as much as 175mg but now less, and a Biologic together, Humira didnt work for me but Remicade did.  Until I took both together nothing really worked other than prednisone which we all know is a poor long term solution. Hopefully your doctor finds the right mix. Don't be afraid to seek out the best local hospital specialist to confirm what course your Gastro doctor suggests. You are talking about a lifelong disease so more opinions never hurt.

Reply posted for Shar31.

Thank you:)  That does make me feel better about the biologic (Humira).  So far so good, as we started it.  Now we are just trying to fatten him up...his weight is a yoyo, and he's too skinny.  Hard to control a teens diet with their social lives!  Best of luck to you as well:)

Reply posted for jrichins.

I was hesitant to go to a biologic as well but was scheduled to start today (starting a post with my experience).  At one point, I took Imuran (azathioprine) for about 9 years and was flare-free, along with Asacol.  I often had sinus infections or would get a sore throat in the late afternoon which would disappear with some Tylenol and a night's sleep. These lessons when I stopped working in an office building and worked at home.   I stopped Imuran and remained flare-free for about 3 more years until the past year.
Now, I am back on azathioprine and mesalamine (Asacol) and finished prednisone recently.  I am adding a biologic after getting a second opinion. 

Due to a recent flare, I visited a doctor at Penn Medicine at their Inflammatory Bowel Disease center. He explained to me that prednisone and azathioprine are the two worst medicines, in terms of UC treatment side effects.  I respect his opinion since they do so much research there and are recognized globally.  
I was hesitant to move to a biologic, too, but I remind myself of what he said about side effects. Also, he said the risk of colon cancer due to severe inflammation is higher than the risk of cancer from a biologic.
Something to consider and discuss with your doctor.
Good luck.

Reply posted for haymikey.

Thank you for your responses:)

Reply posted for jrichins.

Imuran made me deathly ill.  I’m now considered allergic to it.  Remicade and entyvio I’ve been on  and both did nothing for me.  good luck. Everyone reacts differently.

Reply posted for jrichins.

For what it's worth, I've been on Purinethol ( a slightly different molecular version of Imuran) for 30 years now... with 1 flare in 30 years.  Before giving up on Imuran you may ask the Dr. to do a 'Thioprine Metabolites' blood test to better determine what the optimum dosage may be for your son. He me need a higher dosage.  Most doctors seem to prescribe dosage by body weight alone... but each of us metabolizes Imuran differently, and some may require more... some less.  And for some, the drug simply will not work.  This was a miracle drug for the last 30 years.  I've been symptom free.  But now I'm concerned about toxicity to my bone marrow, and may need to switch to another medicine... but again, this was a blessing.  Good luck and God bless.

Reply posted for jrichins.

Just seeing if anyone had comments on my original post.  Dr. is feeling Imuran has more risks, and may not be a long term solution.  What are others experiences with Imuran and/or Biologics?